Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/2345
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dc.contributor.authorBalant, Luc P.-
dc.contributor.authorGex-Fabry, Marianne-
dc.date.accessioned2019-11-28T05:31:12Z-
dc.date.available2019-11-28T05:31:12Z-
dc.date.issued2000-
dc.identifier.urihttp://hdl.handle.net/123456789/2345-
dc.description.abstractWith the advancement of both biological and computer sciences, new drug development faces the challenge to integrate a huge amount of knowledge accumulated from the very early quantitative structure±activity relationship investigations of the candidate molecule to the large scale clinical trials in patients. Whereas pharmacokinetics and pharmacodynamics are ®elds in which modelling has long demonstrated its value, its potential in many other areas of drug development has recently been the object of intensive scienti®c activity. The present review places emphasis on these newer applications; it includes the opinion of many experts in often highly specialised areas such as in vitro to in vivo extrapolation, toxicokinetics, non-continuous response models, population approaches and computer assisted simulation of clinical trials. It is most probable that in the near future many of these areas of research will be the objects of intensive and interesting developments. This will undoubtedly lead to improve developmental strategies for new drugs as well as more individualised pharmacological strategies for patients.en_US
dc.publisherELSEVIERen_US
dc.subjectDrug developmenten_US
dc.subjectModellingen_US
dc.titleModelling during drug developmenten_US
dc.typeArticleen_US
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